The best Biotech ETFs
How to invest in biotech using ETFs
How do I invest in biotech stocks?
The main objective of biotech companies is to develop new or more efficient methods of diagnosis and ways of producing chemical compounds. For this purpose, knowledge from various fields of natural science is employed, mostly in combination with the latest digital technology. The outcomes are then used in medicine, agriculture or industry.Biotech indices track companies that are active in these fields as well as firms that provide the relevant infrastructure.
In this investment guide, you will find all the ETFs that give you exposure to biotech stocks. Currently, there is 3 index available tracked by 5 ETFs.
Nasdaq Biotechnology performance
Biotech ETFs in comparison
When choosing a biotech ETF one should consider several other factors in addition to the methodology of the underlying index and performance of an ETF. For better comparison, you will find a list of all biotech ETFs with details on size, cost, age, income, domicile and replication method ranked by fund size.
Compare all biotech ETFs in detail
Compare all biotech ETFs in a chart
| Provider ISIN | Fund size in m EUR | TER in % | Use of profits | Fund domicile | Replication method | |
|---|---|---|---|---|---|---|
| iShares Nasdaq US Biotechnology UCITS ETFIE00BYXG2H39 | 478 | 0,35% p.a. | Accumulerend | Ierland | Geoptimaliseerde sampling | |
| Invesco Nasdaq Biotech UCITS ETFIE00BQ70R696 | 285 | 0,40% p.a. | Accumulerend | Ierland | Niet-gefinancierde swap | |
| iShares Nasdaq US Biotechnology UCITS ETF USD (Dist)IE00BDZVHG35 | 29 | 0,35% p.a. | Distribueren | Ierland | Geoptimaliseerde sampling | |
| Global X Genomics & Biotechnology UCITS ETFIE00BM8R0N95 | 9 | 0,50% p.a. | Accumulerend | Ierland | Volledige replicatie | |
| WisdomTree BioRevolution UCITS ETF USD AccIE000O8KMPM1 | 4 | 0,45% p.a. | Accumulerend | Ierland | Volledige replicatie |
Source: justETF.com; As of 20-02-2025
Return comparison of all biotech ETFs
The table shows the returns of all biotech ETFs in comparison. All return figures are including dividends as of month end. Besides the return the reference date on which you conduct the comparison is important. In order to find the best ETFs, you can also perform a chart comparison.
| ETF | 1 month in % | 3 months in % | 6 months in % | 1 year in % | 3 years in % | |
|---|---|---|---|---|---|---|
| Invesco Nasdaq Biotech UCITS ETF | 5,07% | 2,12% | -2,36% | 8,21% | 18,30% | |
| iShares Nasdaq US Biotechnology UCITS ETF USD (Dist) | 5,16% | 2,11% | -2,30% | 8,14% | 18,41% | |
| iShares Nasdaq US Biotechnology UCITS ETF | 4,98% | 2,10% | -2,32% | 8,03% | 18,13% | |
| WisdomTree BioRevolution UCITS ETF USD Acc | 5,14% | 2,60% | -6,25% | -0,06% | -18,80% | |
| Global X Genomics & Biotechnology UCITS ETF | 4,86% | 2,68% | -8,73% | -1,29% | -30,93% |
| ETF | 2025 in % | 2024 in % | 2023 in % | 2022 in % | 2021 in % | |
|---|---|---|---|---|---|---|
| iShares Nasdaq US Biotechnology UCITS ETF USD (Dist) | 5,16% | 5,17% | 0,76% | -5,13% | 8,09% | |
| Invesco Nasdaq Biotech UCITS ETF | 5,07% | 5,34% | 0,54% | -4,94% | 7,96% | |
| WisdomTree BioRevolution UCITS ETF USD Acc | 5,00% | -8,76% | -6,11% | -21,49% | - | |
| iShares Nasdaq US Biotechnology UCITS ETF | 4,98% | 5,43% | 0,53% | -5,02% | 7,94% | |
| Global X Genomics & Biotechnology UCITS ETF | -2,40% | -10,84% | -11,72% | -32,85% | - |
Source: justETF.com; As of 31-01-2025; Calculations in EUR including dividends